Helicobacter pylori is involved in gastric diseases such as ulcers and carcinomas. Urease is an important virulence factor produced by this bacterium.
ircular RNAs comprise a new class of long noncoding RNAs characterized by their 5'and 3'ends covalently joined. They were misinterpreted as splicing errors for more than 20 years until their rediscovery in 2012 as diverse, highly abundant, conserved and naturally occurring RNAs in eukaryotes.
Gastric cancer is the 5th most common cancer and 3rd most common cause of cancer-related mortality globally. Disease incidence varies among different regions within countries and among ethnicities.
Persistent inflammation in the gastric antrum caused by Helicobacter pylori (H. pylori) increases the risk of developing duodenal ulcer, in contrast, when gastritis predominates in the stomach body, generates atrophic gastritis and increased risk for the development of gastric cancer.
The presence of enterohepatic Helicobacter species (enterohepatic Helicobacter spp., EHS) is considered universal in colonies of experimentation mice.
Gastric infection by Helicobacter pylori is considered a risk factor for gastric and duodenal cancer, and extragastric diseases like cardiovascular and neurodegenerative pathologies.
