Gastric cancer (GC) is the fifth most common cause of cancer death worldwide with approximately one million cases diagnosed annually.
Although Helicobacter pylori is causally associated with gastric cancer, <1% of infected individuals develop this malignancy. H. pylori infection induces gastritis that variably progresses to atrophy, intestinal metaplasia (IM), dysplasia and cancer.
Helicobacter pylori is the most important pathogen associated with gastric diseases, including gastric cancer. Cytotoxin-associated gene A (CagA) is an oncoprotein and a major virulence factor of H. pylori.
astric cancer (GC) is the third leading cancer-related cause of death worldwide, being the Andean region of Latin America a high-risk zone.
The Helicobacter pylori type IV secretion system (T4SS) encoded by the cag pathogenicity island forms needle-like pili, whose binding to the integrin-β1 receptor results in injection of the CagA oncoprotein.
Reprimo (RPRM) is a tumor suppressor gene, frequently silenced by DNA methylation during advanced stages of gastric cancer (GC). Loss of expression of RPRM in GC has been associated to increased invasiveness and poor prognosis.
