CAMPYLOBACTER PYLORIDIS IN TEH UPPER GASTROINTESTINAL TRACT: A BRAZILIAN STUDY +
Luiz Gonzaga Vaz COELHO1, Satya Sundar DAS2, Quazi Najma KARIM3, Marjorie Mary WALKER4, Dulciene Maria de Magalhães QUEIROZ5, Ediberto Nogueira MENDES6, Geraldo Ferreira LIMA JR.7, Celso Affonso de OLIVEIRA8; Jeremy Hufh BARON9 and Luiz de Paula CASTRO10
COELHO LGV, DAS SS, KARIM QN, WALKER MM, QUEIROZ DM de M, MENDES EN, LIMA JR GF, OLIVEIRA CA de, BARON JH, CASTRO L de P - Campylobacter pyloridis in the upper gastrointestinal tract: a Brazilian study. Arq Gastroenterol, São Paulo, 24(1):5-9,1987.
ABSTRACT: The successful isolation of C. pyloridis from human gastric mucosa has renewed interes in these bacteria and their role as a causative agent for gastritis, and possible causal relationship between chronic gastritis and peptic ulceration. To determine the incidence of C. pyloridis in gastric biopsies we studied 51 consecutive Brazillian patients with a wide range of alimentary disorders presenting for endoscopy. At least three biopsies were performed to identify the bacteria. The organism was found in 40/51 (78%) of patients. These was a close corrlation between culture (100%), Gram (90%) and Gimenez staining (80%) in identifying the bacteria. All C. pyloridis positive patients had histological evidence of antrai chronic ulcer patients (n = 17) showed C. pyloridis in the antrum. In The duodenum the bacteria were mainly seen in gastric type os mucosa. Our findings support the hypothesis that C. pyloridis is etiologically related to gastritis an possibly peptic ulceration.
KEY WORDS: Campylobacter pyloridis*, Gastritis*, Peptic ulcer*.
Spiral bacteria in gastric mucosa were noted by histopathologists for many years before their identification by MARSHALL and WARREN (14), by culture of gastric antral biopsies.
The Gram-negative flagellate and microaerophilic bacterium is now officially named Campylobacter pyloridis (24), and is stromgly associated with chronic gastritis. There is speculation that this bacterium may be implicatec in peptic ulceration (14,15).
C.pyloridis has now been isolated from patients with gastritis and peptic ulcer in many countries. There are no reports about C. pyloridis infection in Brazil. The purpose of this study in different parts of the upper gastrointestinal tract of Brazillian patientis with a wide range of alimentary disorders and to correlate the incidence with that reported in other countries.
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