Gastric carcinogenesis, in the form of intestinal-type gastric cancer (GC), consists of a series of sequential lesions known as Correa's multistep cascade of gastric cancer.
Gastric cancer is the fifth commonest incident malignancy represents 6.8% of the cancers (952,000 cases/2012)and it is the third leading cause of death by cancer for both genders worldwide 8.8% (723,000 deaths), Epidemiologic studies have shown the positive impact of the Mediterranean Diet.
Helicobacter pylori is a Gram-negative bacterium that colonizes the gastric mucosa in humans. One of the main virulence factors of H. pylori is the cag pathogenicity island.
A recently published study from our lab demonstrated that H. pylori activation of the PI3K-AKT-mTOR pathway in gastric cells, increased hypoxia-induced factor (HIF)-1α expression, which accelerated the post-translational down-regulation of Cyclin D1.
The presence of bacteriophages related with Helicobacter pylori has been documented from the first reports about findings of these bacteria and several phages have been reported in the genome of H. pylori.
ELISA serology to detect anti-H. pylori IgG antibody is a practical and low cost test. In our country there is no available noninvasive test widely used to diagnosis H. pylori infection.
