The Helicobacter pylori type IV secretion system (T4SS) encoded by the cag pathogenicity island forms needle-like pili, whose binding to the integrin-β1 receptor results in injection of the CagA oncoprotein.
Reprimo (RPRM) is a tumor suppressor gene, frequently silenced by DNA methylation during advanced stages of gastric cancer (GC). Loss of expression of RPRM in GC has been associated to increased invasiveness and poor prognosis.
Histopathological changes in gastric mucosa during Helicobacter pylori (HP) infection can be associated with HP fitness adaptation through genetic events.
The C-urea breath test is the main non-invasive test for the diagnosis of Helicobacter pylori infection. Its availability around the country is scarce, mainly due to the difficulty of obtaining the labeled isotope from abroad.
The Helicobacter pylori infection is the main cause of diseases benign and maligns gastrointestinal. Although, the cure clinical rate has reduced for an increase of antimicrobial resistance in worldwide. For this reason, the search of alternatives that might optimize the effectiveness is a need.
Nos últimos anos, a severidade das infecções pelo Helicobacter pylori (H. pylori) não tem diminuido significativamente. Após erradicação bem sucedida, a taxa de recorrência anual do H. pylori é de aproximadamente 13% devido a infecção da cavidade oral pelo H. pylori.
