astric cancer is one of the most common types of cancer in the world. In Chile, the disease represents the first cause of cancer death in men and the third cause in women, where approximately 3000 individuals died every year from gastric cancer.
Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer (GC) have been largely reported. However, distinct fibrinogen chains and domains have different effects on coagulation, inflammation and angiogenesis.
The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in a portion of GC.
Chile has one of the highest mortality rates due to gastric cancer in the western hemisphere; this as a result of the high incidence of this malignancy and the association to a late diagnosis.
The susceptibility of Helicobacter pylori to antibiotics in the Dominican Republic (DR) has not been monitored. Therefore, we analyzed genome mutations of H. pylori in Dominican patients associated with drug-resistance.
To date, analysis of the complete cag Pathogenicity Island and vacA gene have been carried out mainly by whole genome sequencing of H.pylori strains obtained by culture.
