The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in a portion of GC.
Chile has one of the highest mortality rates due to gastric cancer in the western hemisphere; this as a result of the high incidence of this malignancy and the association to a late diagnosis.
The susceptibility of Helicobacter pylori to antibiotics in the Dominican Republic (DR) has not been monitored. Therefore, we analyzed genome mutations of H. pylori in Dominican patients associated with drug-resistance.
To date, analysis of the complete cag Pathogenicity Island and vacA gene have been carried out mainly by whole genome sequencing of H.pylori strains obtained by culture.
The knowledge about carcinogenesis and the molecular events that lead to cell transformation in gastric cancer (GC) has been a challenge to the scientific community. In this way, studies involving small non-coding RNAs have been widely explored.
Helicobacter pylori (Hp) is the main bacterial agent in gastroduodenal diseases.
