Longitudinal studies of Helicobacter pylori infection acquisition during early childhood with diagnosis established by locally validated noninvasive tests are scarce, particularly at high risk populations.
Helicobacter pylori is a putative risk factor for peptic ulcers and gastric cancer. Current treatment guidelines for H pylori are based on results from developed countries.
In Guatemala, gastric cancer (GC) presents some of the highest rates of incidence and mortality in the world.
Despite decreasing global incidence trends, gastric cancer is still among the five most incident cancers in the world and the third cancer-related cause of death.
Serum pepsinogen 2 (sPG2) level is one of the predictive parameters for gastric cancer (GC) risk but factors that regulate change in PG2 expression are still unknown. Aim of the present study was to investigate genetic variants that may regulated PG2 expression in patients with GC or at risk for GC.
Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer (GC) have been largely reported. However, distinct fibrinogen chains and domains have different effects on coagulation, inflammation and angiogenesis.
